The film begins with Lola (Franka Potente) receiving a phone call from her distraught boyfriend, Manni (Moritz Bleibtreu). He is a small-time criminal and has lost 100,000 marks belonging to his crime boss by accidentally leaving it on a train (Lola was supposed to pick him up, but her moped was stolen while she was buying cigarettes). After the doors of the train closed, he saw a homeless man pick up the bag of money but he was unable to get back onto the train before it left the station. Upon not seeing any trace of his money or the homeless man at the next station, Manni assumes the money is long gone.
Manni has to get the money within 20 minutes before his boss finds out, and plans to rob a nearby supermarket. Lola urges him to wait and tells him she will sort out the money. She decides to ask her father (Herbert Knaup), who is a bank manager.
The main part of the film is divided in three "runs". Each run starts from the same situation but develops differently and has a different outcome. Each run contains various flash-forward sequences, showing how the lives of the people that Lola bumps into develop after the encounter. In each run, those people are affected in different ways.
The film was nominated for 41 awards, including the BAFTA Award for Best Film not in the English Language. It won 26. These included the Audience Award at the Sundance Film Festival, Best Film at the Seattle International Film Festival, and seven separate wins at the German Film Awards.
As of September 2008, the review aggregator Rotten Tomatoes reported that 92% of critics gave the film positive reviews, based on 79 reviews. On Metacritic, another review aggregator, the film had an average score of 77 out of 100, based on 29 reviews, stating the film as having "generally favourable reviews". The Internet Movie Database, IMDb, shows Run Lola Run as having earned 8 out of 10.
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